Fig. 6: BMSC-exos promote fracture healing in mice. | Experimental & Molecular Medicine

Fig. 6: BMSC-exos promote fracture healing in mice.

From: miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/β-catenin signaling pathway

Fig. 6

a PCR was used to detect the level of miR-19b. b Western blot analysis of the protein levels of WWP1, Smurf2, KLF5, and β-catenin in the calli of each group at week 0 after fracture, with β-actin as the internal reference protein. *p < 0.05 compared with the PBS group; #p < 0.05 compared with the control group; NS p > 0.05. c Quantitative analysis of the callus area during femoral fracture healing at the 4th week after fracture. d HE/Alcian blue staining results for evaluating the mineralized callus area. The experimental results are measurement data and are expressed as the mean ± standard deviation values. For multiple comparisons, one-way ANOVA followed by Tukey’s post hoc test was performed. n = 5 in the weeks 0 and 4 after fracture.

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