Fig. 3: Validation of the functional and clinical significance of ESR1 expression in a pooled HCC dataset. | Experimental & Molecular Medicine

Fig. 3: Validation of the functional and clinical significance of ESR1 expression in a pooled HCC dataset.

From: YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior

Fig. 3

a Heatmap showing the shared differentially upregulated (ESR1-L; n = 63) and downregulated (ESR1-H; n = 199) genes in a pooled dataset including GSE87630, GSE4024, and GSE14520. The DEGs in the pooled dataset were defined as genes with a fold change >1 and were assessed using Student’s t-test (p < 0.01) in the comparison of ESR1-H with ESR1-L. b Boxplots showing the oncoactivity score (the enrichment score for the transition from an oncogene to a TSG signature) of each group. c Plots showing the serum levels of AFP in the Yonsei cohort and TCGA-LIHC. d Kaplan–Meier OS curve for patients with ESR1-H and ESR1-L HCCs.

Back to article page