Fig. 5: Ectopic UBXN8 expression induces cell cycle arrest, reprograms myeloid differentiation, suppresses colony formation and inhibits proliferation.
From: Epigenetic silencing of UBXN8 contributes to leukemogenesis in t(8;21) acute myeloid leukemia
a, b Flow cytometric analysis of cell cycle distribution showed that ectopic UBXN8 expression induced G1 arrest. c A colony formation assay was performed on SKNO-1 cells transduced with control or UBXN8 lentiviral vector and cultured for 8 days. d Flow cytometric analyses of CD11b expression showed that ectopic UBXN8 expression increased myeloid differentiation. e The CCK-8 assay was performed on SKNO-1 cells transduced with control or UBXN8 lentiviral vector at the indicated time points. Error bars show the SD from three different assays (*P < 0.05, **P < 0.01, ***P < 0.001).
