Fig. 4: Functional analysis of super-enhancer differentially methylated region (seDMR) targets and enrichment of lung squamous cell carcinoma (LUSC) risk-related single nucleotide polymorphisms (SNPs) for DMRs. | Experimental & Molecular Medicine

Fig. 4: Functional analysis of super-enhancer differentially methylated region (seDMR) targets and enrichment of lung squamous cell carcinoma (LUSC) risk-related single nucleotide polymorphisms (SNPs) for DMRs.

From: The importance of enhancer methylation for epigenetic regulation of tumorigenesis in squamous lung cancer

Fig. 4

a Stacked bar plots of the number of seDMRs, functional (F)-seDMRs, and their target genes with hypo- or hypermethylation. b Enrichment of Reactome pathway gene sets for F-seDMR target genes. c An example of seDMR and target interactions visualized with Integrative Genomic View (IGV). Methylation levels of seDMR regions and expression levels of their target genes were compared between tumor (T) and normal tissue (N). d An example of LUSC risk-related SNPs residing within DMR regions. e Pie chart for the distribution of LUSC risk-related SNPs within DMRs and outside of DMRs. The significance of SNPs within DMRs was assessed using binomial distribution.

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