Fig. 1: CU06-1004 exerts a cardioprotective effect by reducing vascular permeability in I/R injury. | Experimental & Molecular Medicine

Fig. 1: CU06-1004 exerts a cardioprotective effect by reducing vascular permeability in I/R injury.

From: CU06-1004 enhances vascular integrity and improves cardiac remodeling by suppressing edema and inflammation in myocardial ischemia–reperfusion injury

Fig. 1

a Scheme of the experiment to determine the cardioprotective effect of CU06-1004 in I/R injury. b Representative images from the Evans blue staining and TTC assay at 48 h after reperfusion; red dotted line: area at risk; yellow line: necrotic area. c, d Quantification results of (c) area at risk and (d) necrotic area. n = 6. *P < 0.05 vs. vehicle. †P < 0.05 vs. low CU06-1004. N.S. not significant. e Representative images of the cardiac edema assay at 48 h after reperfusion. f Quantification of Evans blue leakage into interstitial tissue; blue area: extravasation of Evans blue. n = 7. *P < 0.05 vs. vehicle. †P < 0.05 vs. low CU06-1004. Data are shown as the mean ± SEM.

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