Table 2 The immunostimulatory functions and mechanism of mushrooms and B. subtilis chungkookjang.
From: Immunomodulatory functional foods and their molecular mechanisms
Source | Cell type | Function | Model | Reference |
|---|---|---|---|---|
A. blazei | Splenocytes | IFN-γ, IFN-γ-IP-10↑ IL-1β, IL-4, IL-6↑ Cell proliferation↑ | Animal | |
PBMCs | Phagocytosis↑ | Animal | ||
NK cells | IFN-γ↑ | Animal | ||
G. lucidum | Splenocytes | IFN- γ, IL-2, Cell proliferation↑ | Animal | |
Macrophages | TNF-α, IL-6, IL-1β↑↑ Phagocytosis, NO↑ | In vitro, animal | ||
NK cells | Cytotoxicity↑ IL-2, IFN- γ, CD56+ cells↑ | Animal, human | ||
G. frondosa | Splenocytes | IFN- γ, TNF-α, IL-12 p70, IL-18↑ | Animal | |
Macrophages | IL-12↑ | Animal | ||
NK cells | TNF-α, Cytotoxicity↑ | Animal | ||
DCs | IL-12 p70↑ | Animal | ||
T cells | TNF-α, IFN-γ↑ Foxp3+ CD4+ cells↓ | Animal, human | ||
APCs | IFN-γ, IL-12↑ | Animal | ||
B. subtilis chungkookjang (γ-PGA) | PBMCs | Cytotoxicity↑ | Human | |
Macrophages | TNF-α, IFN-γ-IP-10↑ NLRP3, IL-1, IL-6, IL-10↑ | Ex vivo | ||
NK cells | Cytotoxicity, IFN-γ↑ | Animal | ||
DCs | IL-12↑ | Ex vivo | ||
Natural killer dendritic cells | IL-12, IL-23, IFN-γ↑ Perforin, FasL, TRAIL↑ | Ex vivo, animal | ||
T cells | IFN-γ-expressing CD8+ cells↑ | Animal |
