Fig. 1: The structure and modification of HMGB1. | Experimental & Molecular Medicine

Fig. 1: The structure and modification of HMGB1.

From: The mechanism of HMGB1 secretion and release

Fig. 1

HMGB1 consists of three domains: two DNA binding domains (Box A and Box B), a C-terminus and an N-terminus. HMGB1 undergoes various posttranslational modifications after cell activation induced by external stimuli, resulting in its translocation from the nucleus to the cytoplasm and finally its release. Ac, acetylation; Ar, ADP-ribosylation; Cys, cysteine; Gly, N-glycosylation; Me, methylation; NLS1/2, nuclear localization signal 1/2; Ox, oxidation; P, phosphorylation.

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