Fig. 8: Schematic illustrating the protective effect and mechanism of Sestrin2 in cholestatic liver injury. | Experimental & Molecular Medicine

Fig. 8: Schematic illustrating the protective effect and mechanism of Sestrin2 in cholestatic liver injury.

From: Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis

Fig. 8

Hepatic Sestrin2 expression is induced by ATF4 and C/EBP-β during cholestatic liver injury and thereby inhibits mTORC1 activity. Sestrin2 also suppresses NLRP3 inflammasome activation and subsequently relieves pyroptosis and inflammatory response in cholestatic livers.

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