Fig. 1: Plasma exosomal miR-204-5p expression is downregulated in rheumatoid arthritis (RA).
From: Identification of novel rheumatoid arthritis-associated MiRNA-204-5p from plasma exosomes
a Volcano plot showing exosomal miRNAs detected by microarrays according to the fold change and P-value. Fold change and P-value were calculated by comparing the differences in exosomal miRNA between the RA patients and the healthy controls. Pink and green circles represent exosomal miRNAs with up and downregulated expression in the RA patients, respectively, (fold change > 2 and P < 0.05). b Differentially expressed exosomal miRNAs in RA displayed as a fold change versus healthy control group. c The expression of exosomal miR-204-5p in the replication group determined by RT-qPCR (n = 60, RA patients vs. healthy controls = 30:30). d The expression of exosomal miR-204-5p in the validation group determined by RT-qPCR (n = 116, RA vs. healthy controls = 56:60). e The expression of serum exosomal miR-204-5p in the sham group and the mice with CIA. n = 3 for each group. f Spearman linear regression analysis of exosomal miR-204-5p levels in plasma and disease activity parameters of the RA patients in the validation group (n = 56). Red numbers indicate statistical significance (P < 0.05). R represents association coefficient. Data are presented as the mean ± SD. P-value was calculated by Student’s t-test, ***P < 0.001. ESR erythrocyte sedimentation rate, CCP cyclic citrullinated peptide antibody, DAS28 disease activity score using 28 joint counts, CRP C-reactive protein.
