Fig. 1: TGF-β2 enhanced pericyte infiltration and transition to myofibroblast in laser-induced Col1α1-GFP transgenic mice. | Experimental & Molecular Medicine

Fig. 1: TGF-β2 enhanced pericyte infiltration and transition to myofibroblast in laser-induced Col1α1-GFP transgenic mice.

From: TGF-β promotes pericyte-myofibroblast transition in subretinal fibrosis through the Smad2/3 and Akt/mTOR pathways

Fig. 1: TGF-β2 enhanced pericyte infiltration and transition to myofibroblast in laser-induced Col1α1-GFP transgenic mice.

a Schematic diagram of intravitreal injection of rAAV2-TGF-β2 or normal saline and laser photocoagulation in Col1α1-GFP transgenic mice. b Western blotting analysis of TGF-β2 in the vitreous humor of mice 2 weeks after intravitreal injection of rAAV2-TGF-β2 or normal saline. c Immunofluorescence analysis of RPE-choroid complex flatmounts. Green, GFP; Red, α-SMA. Scale bar, 100 μm. d Quantitative measurements of GFP-positive areas and α-SMA-positive areas in Panel c (n = 6–8 per group). The data are presented as the mean ± SD. Statistical analyses were performed by Welch’s t test. ***P < 0.001.

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