Fig. 3: miR-200c decreases hepatic fibrogenic and inflammatory gene expression. | Experimental & Molecular Medicine

Fig. 3: miR-200c decreases hepatic fibrogenic and inflammatory gene expression.

From: Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4

Fig. 3: miR-200c decreases hepatic fibrogenic and inflammatory gene expression.

a The effect of miR-200c mimic treatment on fibrogenic gene expression. LX-2 cells were transfected with the control mimic or miR-200c mimic. b qRT–PCR analysis of COL1A1, ACTA2, and TIMP1 mRNA expression. LX-2 cells were transfected with the control inhibitor or miR-200c inhibitor. c Proinflammatory gene expression in LX-2 cells after miR-200c mimic transfection. d The effect of miR-200c inhibitor transfection on CCL3, CCL4, and IL6 mRNA expression. *P < 0.05 and **P < 0.01 indicate a significant difference between the control (or inhibitor) and miR-200c mimic (or inhibitor) (n = 3–4 per group). The data are presented as the mean ± SEM values. Significance was assessed by two-tailed Student’s t-test.

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