Fig. 4: Hyaluronidase-2 expression is elevated in human liver fibrosis. | Experimental & Molecular Medicine

Fig. 4: Hyaluronidase-2 expression is elevated in human liver fibrosis.

From: Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4

Fig. 4: Hyaluronidase-2 expression is elevated in human liver fibrosis.

a STRING protein–protein interaction network of HAS2. b HYAL1 and HYAL2 gene expression in liver samples from patients with fibrosis and chronic HBV. *P < 0.05 and **P < 0.01 indicate a significant difference versus F0/1. c Hepatic HYAL1 and HYAL2 expression in patients with HBV-related liver fibrosis (GEO accession number: GSE84044). Liver fibrosis was staged according to the Scheuer scoring system. The data are presented as the mean ± SEM values. Significance was assessed by one-way ANOVA with Tukey’s post-hoc test. d Mice were injected intraperitoneally with corn oil or CCl4 twice a week for 6 weeks. Representative immunofluorescence images of costaining for HYAL2 (red) and cell-specific markers (green)—F4/80 (a marker of macrophages), Desmin (a marker of HSCs), and CD31 (a marker of endothelial cells)—in the livers of corn oil- or CCl4-injected mice. Nuclei were stained with DAPI (blue). Scale bar, 50 μm.

Back to article page