Fig. 2: The N-domain of SLFNs.
From: Structural, molecular, and functional insights into Schlafen proteins
A Schematic diagram of an SLFN protein. The expanded diagram shows the N-domain of SLFN proteins with the conserved active site. B Sequence alignment of the conserved active site in human, mouse, and virus SLFNs. The sequence alignment was generated using ESPript. C Ribbon diagram of the crystal structure of rSlfn13-N (PDB: 5YD0). BD: bridging domain. D Superimposition of rSlfn13-N, SLFN5-N (PDB: 6RR9), and SLFN12-N (PDB: 7LRE). E The electrostatic surface potentials of rSlfn13-N. The colors indicate electric charge (red: negative and blue: positive). F The electrostatic surface potentials of mSlfn2-N (1-378) (modeled by AlphaFold: AF-Q9Z0I6-F1).
