Table 1 Histone methylation in hypoxia.

MLL1

H3K4

HIF-2α

Activation of HIF-2α expression

Glioma stem cell (387 GSC, 4302 GSC)

1

²⁵

SETD1B

H3K4

CA9, PHD3, VEGF

Activation of hypoxia-inducible genes

Cervical (HeLa), lung (A549), and renal (786-O) cancer

1

²⁶

G9a/GLP

H3K9

HHEX, GATA2, ARNTL

Repression of tumor suppressor genes

Breast cancer (MCF7)

1

²⁴

EZH2

H3K27

E-cadherin, p16INK4A

Repression of E-cadherin and p16 expression

Pancreatic cancer (SW1990)

1

²⁷

LSD1

H3K9me1/me2

MTA1

Activation of MTA1 expression

Breast cancer (MDA-MB-231)

1 or CoCl₂

³⁴

KDM3A

H3K9me1/me2

Overexpressed/maintained

PSA enhancer

Activation of PSA expression

Prostate cancer (LNCaP)

<0.5, 3

⁴⁰

KDM3A

H3K9me2

Overexpressed/maintained

SLC2A3(GLUT3)

Activation of SLC2A3 expression

Endothelial cell (HUVECs)

1

⁴¹

KDM4A

H3K9me3

Maintained

HIF-1α

Activation of HIF-1α expression under mild hypoxic conditions

Colon carcinoma (RKO)

2

⁴²

Inactivated

Suppression of HIF-1α expression under severe hypoxic conditions

<0.1

KDM4B

H3K9me3

Overexpressed/maintained

SLC2A1, ELF3, IFI6, UCA1

Activation of hypoxia-inducible genes

Colorectal cancer (SW480, HCT116)

1

⁴⁴

KDM4C

H3K9me3

Overexpressed/maintained

BNIP3, LDHA, PDK1, SLC2A1, LOXL2, L1CAM

Activation of HIF-1α target genes

Breast cancer (MDA-MB-435), cervical cancer (HeLa)

1

⁴⁵

KDM5A

H3K4me3

Inactivated

BNIP3L, KLF10

Activation of hypoxia-inducible genes

Cervical cancer (HeLa), skin fibroblast (HFF)

1

⁴⁷

KDM5A

H3K4me3

Not changed/inactivated

HMOX1, DAF

Activation of HMOX1, DAF genes

Bronchial epithelial (Beas-2B), lung carcinoma (A549)

1

⁴⁸

KDM6A

H3K27me3

Inactivated

Actc1, Myl1, Myog

Suppression of myogenic differentiation genes

Myoblast (C2C12)

2

⁴⁹

KDM6A

H3K27me3

Overexpressed/maintained

Ncx

Activation of Ncx expression

Primary cardiomyocyte

5

⁵⁰

1

KDM6B

H3K27me3

Overexpressed/maintained

VEGFA

Activation of VEGFA

Endothelial cell (HUVEC)

1

⁵¹