Table 2 Nonhistone methylation in hypoxia.
Name | Substrate | Target gene | Effect | Cell type (cell line) | O2 (%) | Ref. |
|---|---|---|---|---|---|---|
Histone methyltransferases | ||||||
G9a | Reptin K67 | PGK1, VEGF | Repression of HIF-1α target genes | Breast cancer (MCF7) | Not specified | |
Pontin | Est1 | Activation of HIF-1α target genes | Breast cancer (MCF7) | 1 | ||
HIF-1α K674 | NDNF, SLC6A3 | Repression of HIF-1α transactivity | Glioblastoma (U251MG) | 1 | ||
SETD7 | HIF-1α K32 HIF-2α K29 | LDHA, PDK, VEGF | Reduction in SETD7 expression leading to activation of HIF-1α transactivity and HIF-1α stability | Renal carcinoma (RCC4), fibroblast (MEF) | 1 | |
SETD3 | FOXM1 | VEGF | Reduction in SETD3 expression leading to activation of VEGF expression | Cervical cancer (HeLa), glioblastoma (U-87MG) | 1 or CoCl2 | |
Histone demethylases | ||||||
LSD1 | HIF-1α K32me1 | Not determined | Increase in HIF-1α stability | Mouse embryonic fibroblast (MEF), cervical cancer (HeLa) | 1 | |
HIF-1α K391me1 |  | Breast cancer (MDA-MB-231) | 1 or CoCl2 | |||
