Table 3 Histone acetylation in hypoxia.
Name | Substrate | Target gene | Effect | Cell type (cell line) | O2 (%) | Ref. |
|---|---|---|---|---|---|---|
Histone acetyltransferases | ||||||
p300/CBP | Â | EPO, VEGF | Activation of EPO and VEGF expression | Hepatocellular carcinoma (Hep3B) | 1 | |
TIP60 | H3K9 | ANKRD37 | Activation of hypoxia-inducible genes | Colorectal cancer (HCT116) | 1 | |
Histone deacetylases | ||||||
HDAC1 | H3ac | lncRNA CF129 | Suppression of lncRNA CF129 | Pancreatic cancer (PANC-1, BxPC-3) | 1 | |
lncRNA FAM99A | Suppression of lncRNA FAM99A | Hepatocellular carcinoma (Hep3B, SK-Hep-1) | 1 | |||
HDAC3 | H3K4ac | E-cadherin | Suppression of epithelial genes | Hypopharyngeal carcinoma (FaDu), breast cancer (MCF7) | 1 | |
H3K9ac | miR-627–5p | Suppression of miR-627–5p | Hepatocellular carcinoma (Hep3B, SMMC-7721) | 1 | ||
HDAC9 | H3K9ac | Atg7, Beclin1, LC3 | Suppression of autophagy genes | Myoblast (C2C12) | 1 | |
