Table 1 8-oxo-dG repair pathways.
From: 8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification
8-Oxo-dG repair pathway | DNA lesion (substrate) | Damage recognition and removal | Downstream repair proteins | Reference |
|---|---|---|---|---|
Base excision repair (BER) | 8-oxo-dG | OGG1 → APE1 | Short-patch BER: DNA pol β, DNA ligase III/XRCC1 | |
OGG1 → APE1 | Long-patch BER: DNA pol β, DNA ligase I, FEN1, PCNA, RFC, RPA, DNA pol δ or pol ε | |||
8-oxo-dG coupled with A | MUTYH → APE1 | DNA pol β, DNA pol λ | ||
8-oxo-dG but mainly fapyG, fapyA | NEIL1 → PNK | DNA pol β, DNA ligase III/XRCC1 | ||
Hydrolysis | 8-oxo-dGTP | MTH1 | N/A | |
Transcription-coupled nucleotide excision repair (TC-NER) | 8-oxo-dG | CSB, XPC → APE1 | ||
Mismatch repair (MMR) | 8-oxo-dG coupled with A | MSH2/6, MUTYH | PCNA | |
Others | 8-oxo-dG | MPG, RPS3 | Unknown |
