Fig. 1: RNA profiling of TNF-α-stimulated fibroblast-like synoviocytes (FLSs). | Experimental & Molecular Medicine

Fig. 1: RNA profiling of TNF-α-stimulated fibroblast-like synoviocytes (FLSs).

From: Inhibiting peripheral and central MAO-B ameliorates joint inflammation and cognitive impairment in rheumatoid arthritis

Fig. 1

a Schematic showing the experimental design for bulk RNA-seq. b RNA-seq detected 1328 DEGs between naive (n = 4, biologically independent) and TNF-α-induced FLSs (n = 3, biologically independent). c Top 20 pathways altered in FLSs, which were identified by Partek flow pathway analysis. The log2 fold change and –log2 FDR are shown. d Heatmap (left) and volcano plot (right) of the genes listed in the rheumatoid arthritis pathway. e Heatmap (left) and volcano plot (right) of the genes listed in the phenylalanine metabolism pathway. f–i Volcano plot of the genes listed in GABA-related transcripts. The red circle in the graph indicates significant upregulation; the blue circle indicates significant downregulation; FDR ≤ 0.05, and fold change >± 2.

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