Fig. 7: IL-1β is sufficient for aberrant astrocytic GABA in the hippocampus. | Experimental & Molecular Medicine

Fig. 7: IL-1β is sufficient for aberrant astrocytic GABA in the hippocampus.

From: Inhibiting peripheral and central MAO-B ameliorates joint inflammation and cognitive impairment in rheumatoid arthritis

Fig. 7

a Timeline of subcutaneous (s.c.) injection of IL-1ra (5 µg) in CIA mice. b Representative trace of the GABAAR-mediated current in the CA1-hippocampus in control, CIA, CIA + IL-1ra mice. c Amplitude of the tonic GABA current (one-way ANOVA, Tukey’s multiple comparisons test, N = 5, 6, and 2; n = 21, 21, and 5 for CTR, CIA, and CIA + IL-1ra). d Amplitude of the GABA-induced current (one-way ANOVA, Tukey’s multiple comparisons test, N = 3, 3, and 2; n = 8, 7, and 5 for CTR, CIA, and CIA + IL-1ra). e Calculation of the GABA release component (calculated as the tonic current over the GABA-induced full current; one-way ANOVA, Tukey’s multiple comparisons test, N = 3, 3, and 2; n = 8, 7, and 5 for CTR, CIA, and CIA + IL-1ra). f, g Amplitudes and frequencies of sIPSC amplitudes before bicuculline treatment (one-way ANOVA, Tukey’s multiple comparisons test, N = 5, 6, and 2; n = 21, 21, and 5 for CTR, CIA, and CIA + IL-1ra). Error bars in the graphs indicate the SEM. *P < 0.05; **P < 0.01; ***P < 0.001; ns nonsignificant. Statistical details are provided in Supplementary Table 1.

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