Fig. 7: CLU ameliorates mechanical stress-induced LFH in vivo. | Experimental & Molecular Medicine

Fig. 7: CLU ameliorates mechanical stress-induced LFH in vivo.

From: Clusterin negatively modulates mechanical stress-mediated ligamentum flavum hypertrophy through TGF-β1 signaling

Fig. 7: CLU ameliorates mechanical stress-induced LFH in vivo.

a Representative images of H&E, EVG, and Masson staining of tissues from mice under different treatments for 8 weeks. The scale bar indicates 50 μm. b–d Quantitative analysis of the LF area and the ratio of collagen fibers to elastic fibers in EVG and Masson-stained sections (n = 6 mice in each group). Data are expressed as the mean ± S.D. **P < 0.01. ns, not significant. e, g Representative images of immunohistochemical staining for p-SMAD3 and α-SMA in mouse tissues under different treatments after 8 weeks. The scale bar indicates 50 μm. f, h Quantitative analysis of the ratio of p-SMAD3-positive cells and α-SMA-positive cells (n = 6 mice in each group). Data are expressed as the mean ± S.D. **P < 0.01. ns, not significant.

Back to article page