Fig. 1: Exosome inhibitors affect different stages in exosome biogenesis.
From: Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer
Exosomes are generated from endosomes, which are formed by the inward budding of early multivesicular body (MVB) membranes. These cells undergo a series of changes into late MVBs, which can be directed for lysosomal degradation or fusion with the plasma membrane, which leads to the release of exosomes or microvesicles. This image shows potential inhibitors that attenuate exosome biogenesis or release in the exosome manufacturing process.
