Table 1 Exosome biogenesis inhibitors.
From: Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer
Name | Chemical Structure | Molecular Weight | Molecular Target | Biological Effects |
|---|---|---|---|---|
Pantethine |
| 554.72 | Coenzyme A | - Regulation of lipid or cholesterol metabolism - Reduction in microvesicle (MV) release from breast cancer cells |
GW4869 |
| 577.50 | Neutral sphingomyelinase (nSMase) | - Neutral sphingomyelinase (nSMase) inhibitors - Inhibition of exosomes generation and MV shedding |
Imipramine |
| 280.19 | Acid sphingomyelinase (aSMase) | - Acid sphingomyelinase (aSMase) inhibitors - Regulation of membrane fluidity, exosomes release, and MV generation |
Spiroepoxide |
| 378.46 | Neutral sphingomyelinase (nSMase) | - Natural product, irreversible inhibitors of neutral sphingomyelinase (nSMase) |
DPTIP |
| 378.44 | Neutral sphingomyelinase (nSMase 2) | - Neutral sphingomyelinase 2 (nSMase) inhibitor with nanomolar potency |
Simvastatin |
| 418.56 | HMG-CoA reductase | - HMG-CoA reductase inhibitor - Regulation of lipid, including cholesterol, metabolism |
Glibenclamide (Glyburide) |
| 494.00 | ATP-binding cassette transporter | - Inhibition of ATP-binding cassette transporter - Regulation of potassium channels |
Indomethacin |
| 357.78 | Cyclooxygenase I and II | - Nonsteroidal anti-inflammatory drug - Regulation of ABCA3 or transporter and lipid transporter |
