Fig. 1: USP15 was overexpressed in the lung tissue of PH patients. | Experimental & Molecular Medicine

Fig. 1: USP15 was overexpressed in the lung tissue of PH patients.

From: USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner

Fig. 1

Three mRNA expression datasets (GSE113439, GSE15197, and GSE53408) were selected to identify DEGs between PAH lung specimens and normal lung specimens. a Overlap of these DEGs are represented by Venn diagrams. b–c DEGs were subjected to GO and KEGG enrichment analyses for functional analysis. The expression levels of USP15, YAP1, and TAZ in PH lung specimens (n = 6) and non-PH lung tissue (n = 3) were further validated by western blotting (d) and real-time PCR (e). f An immunofluorescence assay was conducted to investigate the expression of USP15 (red) and α-SMA (green) in lung tissue from PH patients (n = 1) and controls (n = 1). Scale bar: 50 μm. Data are represented as the mean ± SD.

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