Fig. 1: The dynamics of blood cell production after MPP cotransplantation. | Experimental & Molecular Medicine

Fig. 1: The dynamics of blood cell production after MPP cotransplantation.

From: Lineage tracking to reveal the fate of hematopoietic stem cells influenced by Flk2− multipotent progenitors after transplantation

Fig. 1

a Experimental workflow. A total of 3000 barcoded HSCs with or without 30,000 MPPs were transplanted into each irradiated recipient mouse. Peripheral blood was collected from recipient mice at four-time points after transplantation and sorted into granulocytes (Gr), B cells, CD4 T cells, and CD8 T cells for population and clonal level analyses. b Abundance of granulocytes (Gr), B cells, CD4 T cells, and CD8 T cells in the peripheral blood of the recipient mice. c Abundance of granulocytes (Gr), B cells, CD4 T cells and CD8 T cells in the donor-derived white blood cell (WBC) sample. n = 5 mice for the HSC-only (HSC) group and n = 7 mice for the HSC cotransplanted with MPP (HSC(+MPP)) group in the population level analysis. The data are shown as the mean ± SEM. **P < 0.01 for the comparison of the two experimental groups as determined by one-tailed Student’s t test. WBCs white blood cells.

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