Fig. 5: MPP cotransplantation promotes persistent HSC blood cell production. | Experimental & Molecular Medicine

Fig. 5: MPP cotransplantation promotes persistent HSC blood cell production.

From: Lineage tracking to reveal the fate of hematopoietic stem cells influenced by Flk2− multipotent progenitors after transplantation

Fig. 5

a Diagram illustrating the definition of early, late, and persisted clones based on their blood cell production 2.5 and 6.5 months post-transplantation. b Percentage of all detected barcoded HSC clones that produced granulocytes (Gr), B, CD4 T cells, and CD8 T cells at either 2.5 or 6.5 months post-transplantation. c Venn diagram showing the fraction of early differentiating clones that exhibited various degrees of lineage bias 6.5 months post-transplantation. d Bias between B and T cell production for clones that persisted and exhibited lymphoid specialization as defined in (c). *P ≤ 0.05 and **P < 0.01 for comparison of the two experimental groups as determined by one-tailed Student’s t test.

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