Fig. 5: The remaining dedifferentiated taste receptor cells after GLx form organoids in vitro.
From: Epithelial plasticity enhances regeneration of committed taste receptor cells following nerve injury
a Schematic representation of the experimental procedure for the organoid formation assay. b K8-derived organoids contain mature taste receptor cells indicated by K8 and (c) basal/progenitor cells along the periphery of the organoid as marked by K14. Progenitor cells and proliferative cells are marked by (d) Sox2 and (e) PCNA, respectively, in organoids derived from K8 taste receptor cells after injury. f Schematic of long-term (13 weeks) lineage labeling of K8 cells after GLx. g K8-labeled cells were not observed in CVP at 13 weeks of chasing. h Higher magnification of the boxed area in g. Scale bar: b–e, g-100 µm, h-20 µm.
