Fig. 2: cGAS activation by DNA binding.
From: Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
cGAS binds to dsDNA ≥18 bp and can form dimers when the DNA sequence is sufficiently long or is bent by other factors (e.g., TFAM). Liquid phase condensation leads to the stable ladder/net interaction of cGAS and enhances its catalytic activity.
