Fig. 1: Schematic representation of the DDIAS protein.
From: DDIAS, DNA damage-induced apoptosis suppressor, is a potential therapeutic target in cancer
a, b Comparison of rat, mouse, and human DDIAS proteins. Sequence comparison of human DDIAS protein with mouse DDIAS (noxin) revealed high homology in the N-terminal region containing the DBD C (80.5%; amino acids 1–123) and less homology throughout the rest of the proteins (33.2%; amino acids 124–998). Nuc, nuclear localization signals (red); Zn, zinc-finger-like domain (pink); DNA-PK, DNA-PK phosphorylation consensus sequences (yellow); Akt or ATM, Akt or ATM phosphorylation consensus sequences (yellow); DBD C, DNA binding domain C (Pink); MED29, mediator complex subunit 29 (blue). Potential ubiquitination sites in DDIAS (K386, K500, and K807) are shown.
