Table 2 Multivariate Cox regression analysis for 16 target genes selected by LASSO coefficient profiles according to relapse-free survival (RFS) and 14 chromatic remodeling-associated genes.

No	RMS genes	Coefficients (β)	SE	P	CRMS genes	Coefficients (β)	SE	P
1	SOX2	−2.068	0.552	<0.001	MLL	−0.341	0.693	0.622
2	ATR	−0.510	0.602	0.397	SETD2	0.466	0.432	0.281
3	JAK2	1.975	0.432	<0.001	EP300	−0.884	0.636	0.165
4	FANCG	1.436	0.427	<0.001	KMT2D	0.213	0.331	0.520
5	ZNF217	1.843	0.415	<0.001	BRD4	0.021	1.054	0.984
6	EPHB4	−1.330	1.018	0.191	CREBBP	0.051	0.442	0.908
7	MUTYH	1.204	0.493	0.015	DOT1L	0.484	0.479	0.311
8	AXL	0.367	0.481	0.445	TET2	−0.295	0.626	0.637
9	CD22	−9.944	115.986	0.932	PRDM1	0.278	1.203	0.817
10	CDKN1A	2.836	0.613	<0.001	WHSC1L1	−1.436	1.025	0.161
11	ERBB3	1.745	0.611	0.004	DNMT3A	−0.186	0.597	0.755
12	RAD51D	1.740	0.613	0.005	WHSC1	−16.337	4702.509	0.997
13	STAT3	2.194	0.623	<0.001	HDAC1	−16.330	4745.240	0.997
14	ABL1	1.365	0.621	0.028	EZH2	1.581	1.424	0.267
15	MITF	2.574	0.741	<0.001	–
16	PAX5	1.003	0.807	0.214	–

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