Fig. 5: TLR7-mediated autophagy modulation of the expression of KIF5A. | Experimental & Molecular Medicine

Fig. 5: TLR7-mediated autophagy modulation of the expression of KIF5A.

From: Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABAA receptor transport in a murine model

Fig. 5

a–d Representative images of Kinesin family member 5 family member (KIF5A, KIF5B, and KIF5C) expression in the hippocampus were detected by western blot (n = 6). Quantitative analysis was performed. ns not significant; **P < 0.01; one-way ANOVA with Tukey’s post hoc test. Bars represent the mean ± SEM. e–i Representative images of autophagy-related proteins (Beclin1, LC3B, and P62) and KIF5A expression in cultured primary neurons were detected by western blot (n = 3). Quantitative analysis was performed. ns, not significant; *P < 0.05; **P < 0.01 versus WT group; #, P < 0.05; ##, P < 0.01 versus WT + IMQ group; &P < 0.05; &&P < 0.01 versus Tlr7−/− +IMQ group. Two-way ANOVA with Dunnett’s post hoc test. Bars represent the mean ± SEM.

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