Fig. 4: Conditional false discovery rate analyses of irritability and psychiatric disorders (schizophrenia, bipolar I disorder and major depressive disorder). | Experimental & Molecular Medicine

Fig. 4: Conditional false discovery rate analyses of irritability and psychiatric disorders (schizophrenia, bipolar I disorder and major depressive disorder).

From: Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders

Fig. 4: Conditional false discovery rate analyses of irritability and psychiatric disorders (schizophrenia, bipolar I disorder and major depressive disorder).

a Conditional Manhattan plot (with a -log10 scale) of conditional false discovery rate (condFDR) values for psychiatric disorders alone (gray) and psychiatric disorders given irritability (red). SNPs with -log10 (condFDR) > 2 (i.e., FDR < 0.01) are shown with large dots. A black line around the dots indicates the most significant SNP in each linkage disequilibrium block. b Comparison of newly-identified significant condFDR variants compared to previously reported variants. A total of 105 variants for SCZ, 54 variants for BD I, and 107 variants for MDD were additionally identified (see Supplementary Tables 14–16). Among the 105 SCZ variants, 45 were replicated in the latest GWAS by Trubetskoy et al. (2022)49. Among the 107 MDD variants, 12 were replicated in the GWAS by Giannakopoulou et al. (2021)50.

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