Table 1 Pan-CAF markers and specific markers for the identification of CAF subtypes.

From: Cancer-associated fibroblasts: from basic science to anticancer therapy

Fibroblast markers3,18

CAF positive markers

CAF negative markers

CAF subtype markers8

myCAF

iCAF

apCAF

ACTA2

PDGFRα / PDGFRβ19

CD458

ACTA2

IL6/IL8

H2-Ab1

VIM

DDR220

CD318

TAGLN

PDGFRA

CD74

COL1

COL18

EPCAM8

MMP11

CXCL1/CXCL2/CXCL12; CCL2

SLPI

FSP1 (also known as S100A4)

FAP8

PECAM118

HOPX

CFD

SAA3

FAP

PDPN8

NG219

POSTN

DPT

 

DES

DCN8

 

TPM1/TPM2

LMNA

 
 

VIM8

  

AGTR1

 
    

HAS1

 
  1. ACTA2 actin alpha 2, VIM vimentin, COL1 collagen type I, FSP1 fibroblast-specific protein 1, FAP fibroblast activation protein, DES desmin, DDR2 discoidin domain-containing receptor 2, PDPN podoplanin, DCN decorin, PECAM1 platelet/endothelial cell adhesion molecule, EPCAM epithelial cell adhesion molecule, TAGLN transgelin, MMP11 matrix metallopeptidase 11, HOPX homeobox transcription factor, TPM1/TPM2 tropomyosin 1/2, CFD complement factor D, DPT dermatopontin, LMNA lamin A, AGTR1 angiotensin II receptor type 1, CXCL CXC-chemokine ligand, Has1 hyaluronan synthase, H2-Ab1 histocompatibility 2, class II antigen A beta 1 gene, SLPI Peptidase inhibitor, Saa3 serum amyloid A3.
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