Fig. 2: DNA methylation affects tumor initiation and progression. | Experimental & Molecular Medicine

Fig. 2: DNA methylation affects tumor initiation and progression.

From: Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential

Fig. 2: DNA methylation affects tumor initiation and progression.

a In pre-adenocarcinoma in the lung, DNA hypermethylation caused by functional mutation of TET downregulates the expression of Wnt antagonist genes, triggering abnormal activation of Wnt signaling and accelerating the formation of early tumor lesions. b DNMT1-mediated hypermethylation of the estrogen receptor (ER) promoter region inhibits the expression of the ER gene during the epithelial-mesenchymal transition, promoting the EMT, which required for metastasis, thereby promoting the proliferation of cancer stem cells in triple-negative breast cancer (TNBC). c Zinc finger ZNF377 negatively regulates the glucose metabolism pathway in tumor cells to exert a significant antitumor effect. d SLC27A6 increases the tumor cell metastatic potential by promoting lipid biosynthesis. DNA hypermethylation downregulates the expression of SLC27A6, which promotes the proliferation of nasopharyngeal carcinoma via the regulation of lipid metabolism.

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