Fig. 1: Bioinformatics analysis revealed TGF-β1 as a key regulator in the development of LFH. | Experimental & Molecular Medicine

Fig. 1: Bioinformatics analysis revealed TGF-β1 as a key regulator in the development of LFH.

From: Decorin: a potential therapeutic candidate for ligamentum flavum hypertrophy by antagonizing TGF-β1

Fig. 1

A The volcano plot shows 570 upregulated DEGs and 457 downregulated genes. B The heatmap shows the top 200 up- and downregulated genes. C Enrichment analysis of biological processes from the GO database. D Enrichment analysis of cell components from the GO database. E Enrichment analysis of molecular function from the GO database. F GSEA of DEGs. G KEGG enrichment analysis of the key pathways involved in LFH. H PPI analysis identified two major modules. I–L The relative expression levels of TGF-β1, COL1A2, FN1, and DCN (n = 4). Data are presented as the means ± SDs. ns, no significance; *p < 0.05; **p < 0.01; ***p < 0.001.

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