Fig. 6: Effect of treatment with a p38 MAPK blocker on cardiac differentiation and heart repair processes. | Experimental & Molecular Medicine

Fig. 6: Effect of treatment with a p38 MAPK blocker on cardiac differentiation and heart repair processes.

From: SOX17-mediated LPAR4 expression plays a pivotal role in cardiac development and regeneration after myocardial infarction

Fig. 6

a Echocardiography (sham heart group, n = 5; MI + PBS group, n = 4; MI + octadecenyl phosphate (ODP) [3 d] group, n = 8; MI + p38 MAPK blocker (SB203580) [3 d] group, n = 4; MI + ODP [3 d] + p38 MAPK blocker [3 d] group, n = 5). LVESD left ventricular end-systolic diameter, LVEDD left ventricular end-diastolic diameter, LVFS left ventricular functional shortening, LVEF left ventricular ejection fraction. b Hearts were fixed, sectioned, and MT stained. c Quantification of percent fibrotic area of MI hearts, analyzed by ImageJ. Statistical analyses were performed using one-way ANOVA (Newman‒Keuls). ns not significant, *p < 0.01, **p < 0.05, ***p < 0.001. Scale bar, 2 mm. All experiments were conducted at least in triplicate.

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