Fig. 2: Post-transcriptional regulation. | Experimental & Molecular Medicine

Fig. 2: Post-transcriptional regulation.

From: Emerging roles of tRNA-derived small RNAs in cancer biology

Fig. 2

a Particular type I or type II tsRNAs bind to target mRNA and induce AGO2-mediated cleavage or mRNA degradation, resulting in gene silencing. b tRF-3a binds to the primer binding site (PBS) in the long terminal repeats (LTR) of endogenous retrovirus (ERV), blocks tRNA priming and inhibits reverse transcription. tRF-3b binds to PBS in the LTR of ERV, induces gene silencing and inhibits reverse transcription.

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