Table 2 List of miRs that indirectly regulate hepatic AMPK function by regulating activators and repressors of AMPK.
From: MicroRNA regulation of AMPK in nonalcoholic fatty liver disease
miR | Organism | Expression in obesity/NAFLD | Direct target | AMPK function | References |
|---|---|---|---|---|---|
miR-10a | Human | Up | RORα | Negative | (Horii et al. 67) |
miR-122 | Human, mouse | Up | SIRT1, CPEB1 | Negative | |
miR-1271 | Human | - | CCNA1 | Positive | (Chen, Zhao, et al. 77) |
miR-130b-3p | Human, mouse | Down | ROCK1 | Positive | (Guo et al. 105) |
miR-130b-5p | Mouse | - | SIRT4 | Negative | (Wang, Wang, et al. 55) |
miR-141 | Human | Up | SIRT1 | Negative | (Yousefi et al. 29) |
miR-146a | Human, mouse | Down | NAMPT, ROCK1 | - | |
miR-199a-3p | Human | Up | LKB1 | Negative | (Lee et al. 50) |
miR-199a-5p | Human, mouse | Up | MST1 | Negative | (Li et al. 69) |
miR-200a-3p | Human, mouse | - | SIRT1 | Negative | (Wu et al. 104) |
miR-20a-5p | Human, mouse | Down | CD36 | Positive | (Wang et al. 73) |
miR-217 | Mouse | Up | SIRT1 | Negative | (Yin et al. 119) |
miR-218 | Human | Up | AdipoR2 | Negative | (Du et al. 62) |
miR-22 | Human, mouse | Up | FGFR1 | Negative | (Hu et al. 30) |
miR-221 | Human, mouse | Up | AdipoR1 | Negative | (Lustig et al. 60) |
miR-29a | Human, mouse | - | CD36 | Positive | (Lin et al. 74) |
miR-320 | Rat | Up | AdipoR1 | Negative | (Wei et al. 61) |
miR-34a | Human, mouse | Up | SIRT1, AdipoR2, NAMPT | Negative | |
miR-378b | Human, mouse | Up | CaMKK2 | Negative | (Wang, Lu, et al. 55) |
miR-448 | Human, mouse | - | MAGEA6 | Positive | (Guo et al. 76) |
miR-451 | Human, mouse | Up | MO25 | Negative | (Hur et al. 27) |
miR-506-3p | Human, mouse | Up | SIRT1 | Negative | (Hu et al. 30) |
miR-519d | Human | - | Rab10 | Positive | (Zhang, Pan, et al. 75) |
miR-665-3p | Mouse | Up | FNDC5 | Negative | (Yu et al. 68) |