Table 2 List of miRs that indirectly regulate hepatic AMPK function by regulating activators and repressors of AMPK.

From: MicroRNA regulation of AMPK in nonalcoholic fatty liver disease

miR

Organism

Expression in obesity/NAFLD

Direct target

AMPK function

References

miR-10a

Human

Up

RORα

Negative

(Horii et al. 67)

miR-122

Human, mouse

Up

SIRT1, CPEB1

Negative

(Jin et al. 120; Long et al. 28)

miR-1271

Human

-

CCNA1

Positive

(Chen, Zhao, et al. 77)

miR-130b-3p

Human, mouse

Down

ROCK1

Positive

(Guo et al. 105)

miR-130b-5p

Mouse

-

SIRT4

Negative

(Wang, Wang, et al. 55)

miR-141

Human

Up

SIRT1

Negative

(Yousefi et al. 29)

miR-146a

Human, mouse

Down

NAMPT, ROCK1

-

(Gong et al. 71; Chen, Tan, et al. 117)

miR-199a-3p

Human

Up

LKB1

Negative

(Lee et al. 50)

miR-199a-5p

Human, mouse

Up

MST1

Negative

(Li et al. 69)

miR-200a-3p

Human, mouse

-

SIRT1

Negative

(Wu et al. 104)

miR-20a-5p

Human, mouse

Down

CD36

Positive

(Wang et al. 73)

miR-217

Mouse

Up

SIRT1

Negative

(Yin et al. 119)

miR-218

Human

Up

AdipoR2

Negative

(Du et al. 62)

miR-22

Human, mouse

Up

FGFR1

Negative

(Hu et al. 30)

miR-221

Human, mouse

Up

AdipoR1

Negative

(Lustig et al. 60)

miR-29a

Human, mouse

-

CD36

Positive

(Lin et al. 74)

miR-320

Rat

Up

AdipoR1

Negative

(Wei et al. 61)

miR-34a

Human, mouse

Up

SIRT1, AdipoR2, NAMPT

Negative

(Lee et al. 52; Wen et al. 63; Choi et al. 90)

miR-378b

Human, mouse

Up

CaMKK2

Negative

(Wang, Lu, et al. 55)

miR-448

Human, mouse

-

MAGEA6

Positive

(Guo et al. 76)

miR-451

Human, mouse

Up

MO25

Negative

(Hur et al. 27)

miR-506-3p

Human, mouse

Up

SIRT1

Negative

(Hu et al. 30)

miR-519d

Human

-

Rab10

Positive

(Zhang, Pan, et al. 75)

miR-665-3p

Mouse

Up

FNDC5

Negative

(Yu et al. 68)