Fig. 13: Molecular pathways in alkaliptosis.
From: Diversity and complexity of cell death: a historical review
This figure illustrates the activation mechanism of alkaliptosis, which is characterized by intracellular alkalinization and subsequent cell death. JTC801 activates the IKK protein complex, which includes CHUK (IKKα), IKBKB (IKKβ), and IKBKG (IKKγ). Then, the IKK protein complex phosphorylates and degrades NFKBIA (IκBα), leading to the nuclear translocation of NFKB1 (p50) or RELA (p65), which regulate gene expression. Furthermore, NF-κB negatively regulates the expression of CA9, a member of the carbonic anhydrase family, to inhibit alkaliptosis.
