Fig. 2: CRF1R structure and BMK-I-152 binding mode. | Experimental & Molecular Medicine

Fig. 2: CRF1R structure and BMK-I-152 binding mode.

From: Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser

Fig. 2

a Schematic of the binding mode with hydrogen bonds and hydrophobic interactions shown as brown and gray dotted lines, respectively. BMK-I-152 can be divided into the following major groups. b An exocyclic alkylamino group, c pyrazolo[1,5-α][1,3,5]triazine, and d an aryloxy moiety. The binding between each group and the CRF1R residue is presented as a cartoon representation.

Back to article page