Fig. 4: Comparison of the CRF1R, BMK-I-152, BMK-C203, and BMK-C205 structures. | Experimental & Molecular Medicine

Fig. 4: Comparison of the CRF1R, BMK-I-152, BMK-C203, and BMK-C205 structures.

From: Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser

Fig. 4

The hydrogen bond R1652.60–Q3557.49, the key bond of the hydrogen-central hydrogen bond network, was compared between CRF1R and BMK-I-152, BMK-C203, and BMK-C205. Brown dotted lines denote hydrogen bonds. The hydrogen bond distances are a 3.0 Å in CRF1R with BMK-I-152, b 3.4 Å in CRF1R with BMK-C203, and c 3.3 Å in CRF1R with BMK-C205. CRF1R antagonist structure of d BMK-I-152, e BMK-C203, and f BMK-C205. Calculating the ligand surface areas of g BMK-I-152, h BMK-C203, and i BMK-C205.

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