Fig. 2: The Cullin-RING E3 ligase family.
From: Targeting E3 ubiquitin ligases and their adaptors as a therapeutic strategy for metabolic diseases
Cullin proteins recruit adaptor proteins (Skp1 for Cul1 and Cul7, Elongin B/C for Cul2 and Cul5, BTB protein for Cul3, and DDB1 for Cul4A and 4B), receptor proteins (F-box proteins for Cul1, VHL-box for Cul2, DCAF for Cul4A and 4B, SOCS for Cul5, and FBXW8 for Cul7), and the RING protein (Rbx1/2) to form CRL E3 ubiquitin ligases that transfer ubiquitin from Rbx1/2-bound E2 to substrate proteins.
