Fig. 6: l-Arginine treatment ameliorates liver inflammation in MCD-induced NASH mice.
From: Lactobacillus plantarum ameliorates NASH-related inflammation by upregulating l-arginine production
a Experimental scheme. b Changes in body weight over time. c Representative photomicrographs of liver sections stained with H&E. Scale bar, 100 μm. d Hepatic lipid levels. e Serum biochemistry levels. f Heatmap of differentially expressed genes (DEGs) from RNA-seq analysis. g Gene ontology analysis of DEGs that were downregulated in l-arginine-treated mice. h Volcano plot depicting genes in g. Inflammatory genes are marked in deep blue. i–k Top 10 GSEA pathways enriched in l-arginine-treated mice compared with vehicle-treated mice based on the hallmark (i) and KEGG (k) pathways. GSEA enrichment plot for TNF-alpha signaling via the nuclear transcription factor-kappa B (NF-κB) pathway (j). *P < 0.05 and **P < 0.01 compared with the vehicle-treated mice, using ANOVA and the post hoc Tukey test. MCD methionine-choline deficient.
