Table 2 Some of the important studies previously published that highlight the role of HIF in stromal cells in diet-induced obesity.
From: Sensing the oxygen and temperature in the adipose tissues – who’s sensing what?
Target cells | Gene | Promoter/Methods | Effects | Phenotype | Body weight gain upon high-fat diet feeding | References |
|---|---|---|---|---|---|---|
ATM | Hif-1α | LysM | ↓ HIF-1α in macrophages | ↑ insulin sensitivity ↑ vascularity in the adipose tissues ↓ tissue hypoxia | No effect | |
↓ ATM infiltration ↓ Ki67-positive proliferating cells | No effect | |||||
− glucose clearance − ATM signature | No effect | |||||
Hif-2α | LysM | ↓ HIF-2α in macrophages | − insulin sensitivity − vascularity in the adipose tissues | No effect | ||
Hif-2α+/− mice treated with clodronate liposomes | Depletion of HIF-2α-positivity in macrophages | ↓ ATM infiltration ↑ insulin sensitivity | No effect | |||
Phd2 | LysM | ↑ HIF-1α, HIF-2α, HIF-3α | ↓ insulin sensitivity | No effect | ||
Endothelial cells | Hif-2α | Stem cell leukemia | ↓ HIF-2α in endothelial cells | − insulin sensitivity − changes in endothelial cell numbers | No effect |
