Table 1 Summary of mt-NAs, their interacting receptors, and the associated human diseases.
From: Mitochondrial nucleic acids in innate immunity and beyond
mt-NA | Interacting receptors | Associated diseases |
|---|---|---|
mtDNA | cGAS | SARS-CoV-236 Nonalcoholic steatohepatitis38 Acute kidney injury40 Rheumatoid arthritis41 Amyotrophic lateral sclerosis42 |
TLR9 | SARS-CoV-2 infection45 Systemic inflammatory response syndrome46 | |
NLRP3 | Acute myocardial infarction50 Systemic lupus erythematosus50 Rheumatoid arthritis51 Type II diabetes51 Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis51 | |
AIM2 | Nonalcoholic fatty acid liver disease and hepatocyte pyroptosis52 Type II diabetes53 | |
mtRNA | RLRs | Aberrant immune responses11 |
TLR3 | Osteoarthritis26 | |
PKR | Osteoarthritis26 Sjögren’s disease57 Huntington’s disease59 |
