Table 1 Properties of CLP isoforms.
From: Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer
CHI3L1 | CHI3L2 | OVGP1 | S1-CLP | |
|---|---|---|---|---|
Biological activities | Carbohydrate and chitin binding | Carbohydrate and chitin binding | Saccharides and oligosaccharides binding | Oligosaccharide, chitin and protein binding |
Expressing cells | Neutrophils, synoviocytes, monocytes/macrophages, osteoclasts, endothelial cell, hepatic stellate cells, smooth muscle cells, and many cancer cells | Synovial fibroblasts, human cartilage chondrocytes, and cancer cells | Oviductal epithelial cell | Macrophages, monocytes, lymphocytes, and sinusoidal endothelial cells, cancer cells |
Possible functions | Regulation of cell proliferation, adhesion, migration, and activation Activation of macrophages Regulation of immune-response in inflammation and cancer | Cartilage biogenesis Type II collagen expression Regulation of immune-response | Supportive role in fertilization and embryo development | A ligand for the multifunctional receptor stabilin-1, macrophage inflammatory regulator, pathogen sensing, endotoxin neutralization |
Associated diseases | Pneumonia, rheumatoid arthritis, breast cancer, colon cancer, ovarian carcinoma, hepatocellular carcinoma, lung cancer, atherosclerosis, atopy, liver fibrosis, depression, schizophrenia, and Alzheimer’s disease, Parkinson disease, obesity, diabetes, asthma etc. | Rheumatoid arthritis, Osteoarthritis, Alzheimer’s disease, renal, glioma and breast cancer | Ovarian cancers, mucinous carcinomas’ hypertension, endometriosis | Rheumatoid arthritis, osteoarthritis chronic obstructive pulmonary disease, sarcoidosis |
