Fig. 3: Regulation of lysosomal Ca2+ homeostasis.
From: Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity
The lysosome contains different classes of Ca2+ channels, including transient receptor potential cation channels of the mucolipin family (TRPML1-3), two-pore channels (TPC1-2), and ionotropic purinergic receptors (P2X4). These channels induce Ca2+ release into perilysosomal domains driven by high Ca2+ gradients, which possibly develop by Ca2+ transfer from the ER or transporters' action related to the acidic luminal pH of the lysosome.
