Fig. 4: Role of mTOR signaling in autophagy regulation at lysosomes.
From: Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity
During activation of mTOR signaling, Rheb and Ragulator induce the localization of mTOR on the lysosomal surface. Autophagic processes mediated by Unc-51-Like Kinase 1 (ULK1) and the phosphatidylinositol 3-kinase (PI3K) complex are negatively regulated by mTORC1 signaling on the lysosome. Perilysosomal Ca2+ release via the TRPML1 channel is critically involved in mTOR activation by promoting interaction with calmodulin (CaM), which in turn causes negative feedback regulation by suppressing TRPML1 activity. FIP200 FAK family kinase-interacting protein of 200 kDa, Rheb Ras homolog enriched in brain, TFEB transcription factor EB, TSC Tuberous sclerosis complex, TRAF6 TNF receptor-associated factor 6.
