Fig. 7: Inhibiting the ISR and blocking the CCL2/7-CCR2 axis ameliorates IDD in vivo. | Experimental & Molecular Medicine

Fig. 7: Inhibiting the ISR and blocking the CCL2/7-CCR2 axis ameliorates IDD in vivo.

From: Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway

Fig. 7

a MRI images (T2WI) of rat caudal vertebrae after 4 weeks of modeling. b The degenerative grades of IVDs were evaluated according to the Pfirrmann grade based on T2WI images. c Quantitative comparison of the water content of IVD tissues in the different groups. d HE and SO staining of the operated segments. e The degenerative grades based on the histological images. f Representative immunohistochemical images and quantitative analysis of CD68, COX2 and CD206 in each group of rat IVD tissues. Experiments were performed 5 times independently, and the data are presented as the means ± SDs. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant, with ANOVA. Bin, bindarit.

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