Fig. 8: CCR2 knockout in MΦs inhibits MΦ infiltration and IDD. | Experimental & Molecular Medicine

Fig. 8: CCR2 knockout in MΦs inhibits MΦ infiltration and IDD.

From: Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway

Fig. 8

a HE and SO staining of CCR2fl/flLyz2-cre and WT mouse IVD tissue. b Immunofluorescence images and quantitative analysis of F4/80+/CCR2+, F4/80+/Cox2+ and F4/80+/CD206+ double-positive cells in the IVD tissue of CCR2fl/flLyz2-cre and WT mice. Experiments were performed 5 times independently, and the data are presented as the means ± SDs. *p < 0.05; **p < 0.01; ***p < 0.001; ns: not significant, ANOVA.

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