Fig. 5: Regulation of IRAlus by APA.
From: Inverted Alu repeats: friends or foes in the human transcriptome
a IRAlus exclusion in MDM2 through 3′ UTR shortening suppresses the p53 pathway. b 3′ UTR lengthening increases the overall expression of immunogenic self-dsRNAs via IRAlus incorporation and triggers innate immune activation.
